SUSTOL—proven 5-day CINV protection to smooth the journey
SUSTOL is indicated in combination with other antiemetics in adults for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of moderately emetogenic chemotherapy (MEC) or anthracycline and cyclophosphamide (AC) combination chemotherapy regimens.
- The unique polymer technology of SUSTOL is engineered to allow for a sustained and controlled release of granisetron to prevent CINV for a full 5 days1,2
- The only 5-HT3 RA to demonstrate superiority in a Phase 3, 3-drug vs 3-drug HEC trial3
- Unscheduled mean CINV-related hydration rate was lower for SUSTOL than for palonosetron in 2 real-world retrospective studies4,5
- Robust safety profile in clinical studies involving >2400 patients1,6,7
Granisetron extended-release injection (SUSTOL) is a Category 1 option in the NCCN Guidelines® for the prevention of acute and delayed emesis due to HEC and MEC.*†‡§II
Granisetron extended-release injection (SUSTOL) is also a preferred option in MEC when used in a combination with dexamethasone in a 2-drug antiemetic regimen.8¶
- When used in recommended antiemetic combination regimens on day 1.
- NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Antiemesis.
- Category 1: Based upon high-level evidence, there is uniform National Comprehensive Cancer Network® (NCCN) consensus that the intervention is appropriate.
- Granisetron extended-release injection is indicated for the prevention of CINV due to MEC and AC combination chemotherapy.
- Granisetron extended-release injection is a unique formulation intended for subcutaneous administration and is NOT interchangeable with the intravenous formulation. Granisetron extended-release injection has an extended half-life and should not be administered at less than 1-week intervals.
- See the NCCN Guidelines for detailed recommendations, including other preferred options.
5-HT3 RA=5-hydroxytryptamine 3 receptor antagonist; AC=anthracycline/cyclophosphamide; CINV=chemotherapy-induced nausea and vomiting; HEC=highly emetogenic chemotherapy; MEC=moderately emetogenic chemotherapy; PK=pharmacokinetics.