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SUSTOL can help prevent nausea and vomiting due to chemotherapy (CINV) for a full 5 days

SUSTOL is a medicine called an antiemetic that may help prevent these side effects1,2

Some antiemetics may fail after just a few days. Because of the unique formulation of SUSTOL, one injection can protect you from chemotherapy side effects for a full 5 days. Based on the type of chemotherapy you have, your doctor may choose SUSTOL as the best option for you. If you have any questions about SUSTOL, ask your healthcare provider.

How SUSTOL works

Polymer injected under the skin

Unique polymer injection

  • SUSTOL is a gel-like formulation containing a polymer that is injected under the skin1
Quick burst of SUSTOL is released

Medication release

  • A quick burst of SUSTOL is released after the injection, followed by a slow and steady release for lasting prevention of nausea and vomiting1,2
Polymer dissolves and leaves body

Polymer dissolves

  • As SUSTOL is being released, the polymer dissolves and leaves the body1,2
SUSTOL can help prevent CINV for a full 5 days
Just one injection can help prevent CINV for a full 5 days—even from some chemotherapies that are likely to cause nausea and vomiting.2

APPROVED USE

SUSTOL is a prescription medicine called an “antiemetic.” SUSTOL is used in adults to help prevent the nausea and vomiting that happens right away or later with certain anti-cancer medicines (chemotherapy).

IMPORTANT SAFETY INFORMATION

Do not receive SUSTOL if you are allergic to granisetron, any of the ingredients in SUSTOL, or any other medicine of this type (5-HT3s) used to help prevent nausea and vomiting.

Injection site reactions may be serious and require medical care. Reactions include infections, bruising, swelling that is caused by blood that collects under the skin (hematoma), bleeding, pain, tenderness, and small bumps (nodules) at the injection site. Some reactions may occur 2 weeks or more after SUSTOL administration. Your risk of severe bruising and hematomas at the injection site is increased if you take a blood thinner medicine (anticoagulant or antiplatelet medicine). Get medical care right away if you have signs of an infection at the injection site or bleeding at the injection site that is severe or lasting more than 24 hours.

Stomach and intestinal problems, such as problems with bowel movement (constipation), may be serious. Tell your healthcare provider if you have constipation or your constipation worsens after you receive SUSTOL. Get medical care right away if you have pain or swelling in your stomach area (abdomen).

Serious allergic reactions have happened in people who received SUSTOL and who have had allergic reactions to other 5-HT3 medicines. These reactions may occur up to 7 days or longer following SUSTOL administration. Get emergency medical help right away if you have any signs or symptoms of a serious allergic reaction including hives, swollen face, breathing trouble, or chest pain.

Serotonin syndrome is a possible life-threatening problem that can happen when taking 5-HT3 medicines, especially when used with some medicines that treat depression and migraine headaches.

Before receiving SUSTOL, tell your healthcare provider about all of your medical conditions, including constipation, recent stomach-area (abdominal) surgery, kidney problems and about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Inform your doctor if you are pregnant or breastfeeding or plan to become pregnant or breastfeed.

The most common side effects of SUSTOL include: injection site reactions, constipation, fatigue, headache, diarrhea, stomach-area (abdominal) pain, trouble sleeping or falling asleep, indigestion, dizziness, weakness, and heartburn.

These are not all the possible side effects of SUSTOL. Ask your healthcare provider or pharmacist for more information. Call your doctor for medical advice about side effects.

You are encouraged to report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Heron at 1-844-437-6611.

SUSTOL is available by prescription only. For more information, please read the Medication Guide.

References:
  1. SUSTOL [prescribing information]. Heron Therapeutics, Inc., 2017.
  2. Ottoboni et al. J Exp Pharmacol. 2014.




APPROVED USE

SUSTOL is a prescription medicine called an “antiemetic.” SUSTOL is used in adults to help prevent the nausea and vomiting that happens right away or later with certain anti-cancer medicines (chemotherapy).

IMPORTANT SAFETY INFORMATION

Do not receive SUSTOL if you are allergic to granisetron, any of the ingredients in SUSTOL, or any other medicine of this type (5-HT3s) used to help prevent nausea and vomiting.

Injection site reactions may be serious and require medical care. Reactions include infections, bruising, swelling that is caused by blood that collects under the skin (hematoma), bleeding, pain, tenderness, and small bumps (nodules) at the injection site. Some reactions may occur 2 weeks or more after SUSTOL administration. Your risk of severe bruising and hematomas at the injection site is increased if you take a blood thinner medicine (anticoagulant or antiplatelet medicine). Get medical care right away if you have signs of an infection at the injection site or bleeding at the injection site that is severe or lasting more than 24 hours.

Stomach and intestinal problems, such as problems with bowel movement (constipation), may be serious. Tell your healthcare provider if you have constipation or your constipation worsens after you receive SUSTOL. Get medical care right away if you have pain or swelling in your stomach area (abdomen).

Serious allergic reactions have happened in people who received SUSTOL and who have had allergic reactions to other 5-HT3 medicines. These reactions may occur up to 7 days or longer following SUSTOL administration. Get emergency medical help right away if you have any signs or symptoms of a serious allergic reaction including hives, swollen face, breathing trouble, or chest pain.

Serotonin syndrome is a possible life-threatening problem that can happen when taking 5-HT3 medicines, especially when used with some medicines that treat depression and migraine headaches.

Before receiving SUSTOL, tell your healthcare provider about all of your medical conditions, including constipation, recent stomach-area (abdominal) surgery, kidney problems and about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Inform your doctor if you are pregnant or breastfeeding or plan to become pregnant or breastfeed.

The most common side effects of SUSTOL include: injection site reactions, constipation, fatigue, headache, diarrhea, stomach-area (abdominal) pain, trouble sleeping or falling asleep, indigestion, dizziness, weakness, and heartburn.

These are not all the possible side effects of SUSTOL. Ask your healthcare provider or pharmacist for more information. Call your doctor for medical advice about side effects.

You are encouraged to report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Heron at 1-844-437-6611.

SUSTOL is available by prescription only. For more information, please read the Medication Guide.