SUSTOL is a prescription medicine called an “antiemetic.” SUSTOL is used in adults to
help prevent the nausea and vomiting that happens right away or later with certain anti-cancer
medicines (chemotherapy).
Do not receive SUSTOL if you are allergic to granisetron, any of the ingredients
in SUSTOL, or any other medicine of this type (5-HT3s) used to
help prevent nausea and vomiting.
Injection site reactions may be serious or severe and require medical care.
Injection site reactions may include infection, prolonged bleeding, bruising, swelling that is
caused by blood that collects under the skin (hematoma), small bump (nodule) at the injection
site, pain or tenderness. Some injection site reactions may occur 2 weeks or more after SUSTOL
administration. Your risk of severe bruising and hematoma at the injection site is increased if
you take a blood thinner medicine (anticoagulant or antiplatelet medicine). Get medical care
right away if you have signs of an infection at the injection site or bleeding at the injection
site that is severe or lasting more than 24 hours.
Stomach and intestinal problems, such as problems with bowel movement
(constipation), may be serious. Tell your healthcare provider if you have constipation or your
constipation worsens after you receive SUSTOL. Get medical care right away if you have pain or
swelling in your stomach area (abdomen).
Serious allergic reactions have happened in people who received SUSTOL and who
have had allergic reactions to other 5-HT3
medicines. These reactions may occur up to 7 days or longer following SUSTOL administration. Get
emergency medical help right away if you have any signs or symptoms of a serious allergic
reaction including hives, swollen face, breathing trouble, or chest pain.
Serotonin syndrome is a possible life-threatening problem that can happen when
taking 5-HT3 medicines, especially when used with
some medicines that treat depression and migraine headaches.
Before receiving SUSTOL, tell your healthcare provider about all of your medical
conditions, including constipation, recent stomach-area (abdominal) surgery, kidney
problems and about all the medicines you take, including prescription and
over-the-counter medicines, vitamins, and herbal supplements. Inform your doctor if you are
pregnant or breastfeeding or plan to become pregnant or breastfeed.
The most common side effects of SUSTOL include: injection site reactions,
constipation, fatigue, headache, diarrhea, stomach-area (abdinal) pain, trouble sleeping or
falling asleep, indigestion, dizziness, weakness, and heartburn.
Report side effects to the FDA at 1-800-FDA-1088 or . Report side effects to
Heron at 1-844-437-6611.
Please see .
PP-SL-0348 | 03/26
